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MuRF1 Antibody

Purified Mouse Monoclonal Antibody

  • E - MuRF1 Antibody AO1993a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • IF - MuRF1 Antibody AO1993a

    Figure 1:Immunofluorescence analysis of Hela cells using MuRF1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

  • FC - MuRF1 Antibody AO1993a
    Figure 2: Flow cytometric analysis of Hela cells using MuRF1 mouse mAb (green) and negative control (red).
  • IHC - MuRF1 Antibody AO1993a
    Figure 3: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using MuRF1 mouse mAb with DAB staining.
  • IHC - MuRF1 Antibody AO1993a
    Figure 4: Immunohistochemical analysis of paraffin-embedded muscle tissues using MuRF1 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q969Q1
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7B8E1
Isotype IgG1
Calculated MW 40.2kDa
Description This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.
Immunogen Synthesized peptide of human MuRF1 (AA: 293-304).
Formulation Purified antibody in PBS with 0.05% sodium azide.
Additional Information
Gene ID 84676
Other Names E3 ubiquitin-protein ligase TRIM63, 6.3.2.-, Iris RING finger protein, Muscle-specific RING finger protein 1, MuRF-1, MuRF1, RING finger protein 28, Striated muscle RING zinc finger protein, Tripartite motif-containing protein 63, TRIM63, IRF, MURF1, RNF28, SMRZ
Dilution E~~1/10000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMuRF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM63
Synonyms IRF, MURF1, RNF28, SMRZ
Function E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti- hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Cellular Location Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity) Localizes to the M- and Z-lines in skeletal muscle.
Tissue Location Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris
Research Areas
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1. Liver Int. 2013 May;33(5):714-21. doi: 10.1111/liv.12128. Epub 2013 Feb 24. 2. Cell Biochem Biophys. 2011 Jun;60(1-2):113-8.

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$ 385.00
Cat# AO1993a
(40 western blots)
Availability: 7-10 days
Bulk Size
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