|Application ||WB, FC, E|
|Description||Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.|
|Immunogen||Purified recombinant fragment of human TFF2 (AA: 20-125) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||Trefoil factor 2, Spasmolysin, Spasmolytic polypeptide, SP, TFF2, SML1|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TFF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).|
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1. Peptides. 2013 Aug;46:1-5.2. Oncol Rep. 2012 Apr;27(4):1207-12.
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