|Application ||WB, IHC, E|
|Description||The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.|
|Immunogen||Purified recombinant fragment of human HDAC10 (AA: 18-219) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide.|
|Other Names||Histone deacetylase 10, HD10, 188.8.131.52, HDAC10|
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HDAC10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|
|Cellular Location||Cytoplasm. Nucleus. Note=Excluded from the nucleoli|
|Tissue Location||Ubiquitous. High expression in liver, spleen, pancreas and kidney|
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Provided below are standard protocols that you may find useful for product applications.
1. J Biol Chem. 2013 Sep 27;288(39):28021-33.2. Biochem Biophys Res Commun. 2007 Nov 23;363(3):776-81.
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