PKHD1 Antibody
Purified Rat Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC, FC, ICC, E |
---|---|
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 8G12A1 |
Isotype | IgG1 |
Calculated MW | 445kDa |
Description | Mutations in the PKHD1 gene, which encodes fibrocystin, cause autosomal recessive polycystic kidney disease (ARPKD). Unfortunately, the lack of specific antibodies to the mouse protein impairs the study of splicing, post-translational processing, shedding, and temporal and spatial expression of endogenous fibrocystin at the cellular and subcellular level. |
Immunogen | Purified recombinant fragment of mouse PKHD1 (AA: 3878-4060) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Dilution | E~~1/10000 WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 FC~~1/200 - 1/400 IHC~~1/200 - 1/1000 |
---|---|
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PKHD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
References
J Am Soc Nephrol. 2011 Dec;22(12):2266-77.Am J Pathol. 2008 Feb;172(2):417-29.
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