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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SLINGSHOT-1L Antibody   


Purified Mouse Monoclonal Antibody

  • E - SLINGSHOT-1L Antibody AO2009a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • IF - SLINGSHOT-1L Antibody AO2009a

    Figure 1:Immunofluorescence analysis of Hela cells using SLINGSHOT-1L mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

  • FC - SLINGSHOT-1L Antibody AO2009a
    Figure 2: Flow cytometric analysis of Hela cells using SLINGSHOT-1L mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WYL5
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1A5C8
Isotype IgG1
Calculated MW 115.5kDa
Description The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Immunogen Synthesized peptide fragment of human SLINGSHOT-1L (AA: 1032-1044 ) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 54434
Other Names Protein phosphatase Slingshot homolog 1,,, SSH-like protein 1, SSH-1L, hSSH-1L, SSH1, KIAA1298, SSH1L
Dilution E~~1/10000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLINGSHOT-1L Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SSH1
Synonyms KIAA1298, SSH1L
Function Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Cellular Location Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion Also localized to the cleavage furrow and the midbody during cytokinesis
Research Areas
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Molecules. 2012 Dec 17;17(12):14975-94.Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun;31(6):928-32.

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$ 385.00
Cat# AO2009a
(40 western blots)
Availability: 7-10 days
Bulk Size
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