|Application ||WB, IHC, FC, ICC, E|
|Description||This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.|
|Immunogen||Purified recombinant fragment of human CD6 (AA: 18-199) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||T-cell differentiation antigen CD6, T12, TP120, CD6, CD6|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cell adhesion. Binds to CD166.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain|
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Provided below are standard protocols that you may find useful for product applications.
J Autoimmun. 2010 Dec;35(4):336-41.Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11724-9.
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