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KBTBD8 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q8NFY9 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 7G8A6 |
| Isotype | IgG1 |
| Calculated MW | 68.8kDa |
| Description | KBTBD8 (kelch repeat and BTB (POZ) domain containing 8) is a protein-coding gene. An important paralog of this gene is KLHL21. |
| Immunogen | Purified recombinant fragment of human KBTBD8 (AA: 264-464) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 84541 |
|---|---|
| Other Names | Kelch repeat and BTB domain-containing protein 8, T-cell activation kelch repeat protein, TA-KRP, KBTBD8, KIAA1842, TAKRP |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KBTBD8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KBTBD8 |
|---|---|
| Synonyms | KIAA1842, TAKRP |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). |
| Cellular Location | Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Translocates to the spindle apparatus during mitosis. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Cell Div. 2013 Apr 11;8(1):3.J Hum Genet. 2010 Jan;55(1):27-31.
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$ 385.00
Cat# AO2031a
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