|Application ||WB, IHC, FC, ICC, E|
|Description||This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]|
|Immunogen||Purified recombinant fragment of human TTR (AA: 1-147) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TTR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.|
|Cellular Location||Secreted. Cytoplasm.|
|Tissue Location||Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver|
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J Biol Chem. 2013 Nov 1;288(44):31752-60.Clin Exp Rheumatol. 2013 May-Jun;31(3):394-9.
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