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IRAK3 Antibody

Purified Mouse Monoclonal Antibody

  • E - IRAK3 Antibody AO2049a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - IRAK3 Antibody AO2049a

    Figure 2:Western blot analysis using IRAK3 mAb against human IRAK3 (AA: 454-596) recombinant protein. (Expected MW is 42.3 kDa)

  • WB - IRAK3 Antibody AO2049a

    Figure 3:Western blot analysis using IRAK3 mAb against HEK293 (1) and IRAK3 (AA: 454-596)-hIgGFc transfected HEK293 (2) cell lysate.

  • IF - IRAK3 Antibody AO2049a

    Figure 4:Immunofluorescence analysis of A549 cells using IRAK3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

  • IF - IRAK3 Antibody AO2049a

    Figure 5:Immunofluorescence analysis of Hela cells using IRAK3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

  • FC - IRAK3 Antibody AO2049a

    Figure 6:Flow cytometric analysis of HepG2 cells using IRAK3 mouse mAb (green) and negative control (red).

  • IHC - IRAK3 Antibody AO2049a

    Figure 7:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using IRAK3 mouse mAb with DAB staining.

  • IHC - IRAK3 Antibody AO2049a

    Figure 8:Immunohistochemical analysis of paraffin-embedded breast cancer tissues using IRAK3 mouse mAb with DAB staining.

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y616
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6G9G2
Isotype IgG1
Calculated MW 67.8kDa
Description This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
Immunogen Purified recombinant fragment of human IRAK3 (AA: 454-596) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 11213
Other Names Interleukin-1 receptor-associated kinase 3, IRAK-3,, IL-1 receptor-associated kinase M, IRAK-M, IRAK3 {ECO:0000312|EMBL:AAH57800.1}
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIRAK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRAK3 {ECO:0000312|EMBL:AAH57800.1}
Function Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Tissue Location Expressed predominantly in peripheral blood lymphocytes.
Research Areas
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1.PLoS One. 2012;7(1):e30414.2.Am J Respir Cell Mol Biol. 2011 Oct;45(4):740-5.

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$ 385.00
Cat# AO2049a
(40 western blots)
Availability: 7-10 days
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