|Application ||WB, IHC, FC, ICC, E|
|Description||The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.|
|Immunogen||Purified recombinant fragment of human CD168 (AA: 306-497 ) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Hyaluronan mediated motility receptor, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility, CD168, HMMR, IHABP, RHAMM|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD168 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity.|
|Cellular Location||Cell surface. Cytoplasm.|
|Tissue Location||Expressed in breast cancer cell lines and in normal breast tissue|
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Provided below are standard protocols that you may find useful for product applications.
1.PLoS One. 2013 Sep 17;8(9):e75681.2.BMC Cancer. 2011 Mar 24;11:106.
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