|Application ||WB, IHC, FC, E|
|Description||CBX4 (chromobox homolog 4) is a protein-coding gene. Diseases associated with CBX4 include brain cancer. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is CBX8.|
|Immunogen||Purified recombinant fragment of human CBX4 (AA: 397-514) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||E3 SUMO-protein ligase CBX4, 6.3.2.-, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CBX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.|
|Cellular Location||Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
1.Cell Stem Cell. 2011 Sep 2;9(3):233-46.2.Ann Surg Oncol. 2013 Dec;20 Suppl 3:S684-92.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.