|Application ||WB, IHC, FC, E|
|Description||This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome|
|Immunogen||Purified recombinant fragment of human RAB11FIP1 (AA: 130-271) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Rab11 family-interacting protein 1, Rab11-FIP1, Rab-coupling protein, RAB11FIP1, RCP|
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB11FIP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.|
|Cellular Location||Recycling endosome. Note=Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC)|
|Tissue Location||Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine|
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1.J Clin Invest. 2009 Aug;119(8):2171-83.2.J Mol Endocrinol. 2005 Oct;35(2):357-72.
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