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RALA Antibody

Purified Mouse Monoclonal Antibody

  • E - RALA Antibody AO2091a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - RALA Antibody AO2091a

    Figure 2:Western blot analysis using RALA mAb against human RALA (AA: 71-203) recombinant protein. (Expected MW is 41.5 kDa)

  • WB - RALA Antibody AO2091a

    Figure 3:Western blot analysis using RALA mAb against HEK293 (1) and RALA (AA: 71-203)-hIgGFc transfected HEK293 (2) cell lysate.

  • WB - RALA Antibody AO2091a

    Figure 4:Western blot analysis using RALA mouse mAb against HepG2 (1), MCF-7 (2), A549 (3), K562 (4), Raji (5), MOLT4 (6), Hela (7), COS7 (8), and NIH3T3 (9) cell lysate.

  • FC - RALA Antibody AO2091a

    Figure 5:Flow cytometric analysis of MCF-7 cells using RALA mouse mAb (green) and negative control (red).

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P11233
Reactivity Human, Mouse, Monkey
Host Mouse
Clonality Monoclonal
Clone Names 4G8B11
Isotype IgG1
Calculated MW 23.6kDa
Description The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
Immunogen Purified recombinant fragment of human RALA (AA: 71-203) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 5898
Other Names Ras-related protein Ral-A, RALA, RAL
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRALA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RAL
Function Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
Cellular Location Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody
Research Areas
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1.Cell Signal. 2012 Jun;24(6):1134-40.2.Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3):735-43.

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$ 385.00
Cat# AO2091a
(40 western blots)
Availability: 7-10 days
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