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SIRT6 Antibody

Purified Mouse Monoclonal Antibody

  • E - SIRT6 Antibody AO2114a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - SIRT6 Antibody AO2114a

    Figure 2:Western blot analysis using SIRT6 mAb against human SIRT6 (AA: 141-250) recombinant protein. (Expected MW is 38 kDa)

  • WB - SIRT6 Antibody AO2114a

    Figure 3:Western blot analysis using SIRT6 mAb against HEK293 (1) and SIRT6 (AA: 141-250)-hIgGFc transfected HEK293 (2) cell lysate.

  • IF - SIRT6 Antibody AO2114a

    Figure 4:Immunofluorescence analysis of HeLa cells using SIRT6 mouse mAb. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

  • IF - SIRT6 Antibody AO2114a

    Figure 5:Immunofluorescence analysis of HeLa cells using SIRT6 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N6T7
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2G1H1
Isotype IgG1
Calculated MW 39kDa
Description This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
Immunogen Purified recombinant fragment of human SIRT6 (AA: 141-250) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 51548
Other Names NAD-dependent protein deacetylase sirtuin-6, 3.5.1.-, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIRT6, SIR2L6
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSIRT6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIRT6
Synonyms SIR2L6
Function NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Cellular Location Nucleus, nucleoplasm. Note=Predominantly nuclear Associated with telomeric heterochromatin regions
Research Areas
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1.Mol Med Rep. 2014 Mar;9(3):882-8.2.Carcinogenesis. 2013 Jul;34(7):1476-86.

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$ 385.00
Cat# AO2114a
(40 western blots)
Availability: 7-10 days
Bulk Size
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