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LRP1 Antibody

Purified Mouse Monoclonal Antibody

     
  • E - LRP1 Antibody AO2134a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

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  • WB - LRP1 Antibody AO2134a

    Figure 2:Western blot analysis using LRP1 mAb against human LRP1 (AA: 20-155) recombinant protein. (Expected MW is 40.8 kDa)

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  • WB - LRP1 Antibody AO2134a

    Figure 3:Western blot analysis using LRP1 mAb against HEK293 (1) and LRP1 (AA: 20-155)-hIgGFc transfected HEK293 (2) cell lysate.

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  • IF - LRP1 Antibody AO2134a

    Figure 4:Immunofluorescence analysis of HeLa cells using LRP1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

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  • IHC - LRP1 Antibody AO2134a

    Figure 5:Immunohistochemical analysis of paraffin-embedded kidney tissues using LRP1 mouse mAb with DAB staining.

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  • IHC - LRP1 Antibody AO2134a

    Figure 6:Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using LRP1 mouse mAb with DAB staining.

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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E
Primary Accession Q07954
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1C8G6
Isotype IgG1
Calculated MW 504kDa
Description The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
Immunogen Purified recombinant fragment of human LRP1 (AA: 20-155) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 4035
Other Names Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1, A2MR, APR
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRP1 (HGNC:6692)
Synonyms A2MR, APR
Function Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2- macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553).
Cellular Location [Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein Membrane, coated pit [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
Tissue Location Most abundant in liver, brain and lung.
Research Areas
Citations (0)
citation

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References

1.Biomed Res Int. 2013;2013:152163.2.J Transl Med. 2012 Aug 8;10:160.

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$ 385.00
Cat# AO2134a
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