|Application ||IHC, FC, ICC, E|
|Description||This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.|
|Immunogen||Synthesized peptide of human SK2 (AA: 36-52).|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Sphingosine kinase 2, SK 2, SPK 2, 18.104.22.168, SPHK2|
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides.|
|Cellular Location||Isoform 1: Cytoplasm. Membrane.|
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1.Tumour Biol. 2014 Jan;35(1):363-8.2.Electrophoresis. 2011 Jun;32(13):1742-9.
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