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SIRT7 Antibody

Purified Mouse Monoclonal Antibody

  • E - SIRT7 Antibody AO2151a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - SIRT7 Antibody AO2151a

    Figure 2:Western blot analysis using SIRT7 mAb against human SIRT7 (AA: 1-105) recombinant protein. (Expected MW is 38 kDa)

  • WB - SIRT7 Antibody AO2151a

    Figure 3:Western blot analysis using SIRT7 mAb against HEK293 (1) and SIRT7 (AA: 1-105)-hIgGFc transfected HEK293 (2) cell lysate.

  • IHC - SIRT7 Antibody AO2151a

    Figure 4:Immunohistochemical analysis of paraffin-embedded liver cancer tissues using SIRT7 mouse mAb with DAB staining.

  • IHC - SIRT7 Antibody AO2151a

    Figure 5:Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using SIRT7 mouse mAb with DAB staining.

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NRC8
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1E2G10
Isotype IgG1
Calculated MW 44.9kDa
Description This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Immunogen Purified recombinant fragment of human SIRT7 (AA: 1-105) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 51547
Other Names NAD-dependent protein deacetylase sirtuin-7, 3.5.1.-, Regulatory protein SIR2 homolog 7, SIR2-like protein 7, SIRT7, SIR2L7
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSIRT7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIRT7
Synonyms SIR2L7
Function NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
Cellular Location Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis
Research Areas
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1.Clin Cancer Res. 2014 Jul 1;20(13):3434-45.2.Mol Cell Proteomics. 2014 Jan;13(1):73-83.

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$ 385.00
Cat# AO2151a
(40 western blots)
Availability: 7-10 days
Bulk Size
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