|Application ||WB, IHC, FC, ICC, E|
|Description||The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.|
|Immunogen||Purified recombinant fragment of human WNT3A (AA: 170-352) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Protein Wnt-3a, WNT3A|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WNT3A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate|
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1.Mol Cell Neurosci. 2013 May;54:44-57.2.J Dermatol Sci. 2011 Dec;64(3):199-209.
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