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FBXL10 Antibody

Purified Mouse Monoclonal Antibody

  • E - FBXL10 Antibody AO2175a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - FBXL10 Antibody AO2175a

    Figure 2:Western blot analysis using FBXL10 mAb against human FBXL10 (AA: 457-555) recombinant protein. (Expected MW is 36.8 kDa)

  • WB - FBXL10 Antibody AO2175a

    Figure 3:Western blot analysis using FBXL10 mAb against HEK293 (1) and FBXL10 (AA: 457-555)-hIgGFc transfected HEK293 (2) cell lysate.

  • WB - FBXL10 Antibody AO2175a

    Figure 4:Western blot analysis using FBXL10 mouse mAb against A549 (1) cell lysate.

  • FC - FBXL10 Antibody AO2175a

    Figure 5:Flow cytometric analysis of HeLa cells using FBXL10 mouse mAb (green) and negative control (red).

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NHM5
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6F6G11
Isotype IgG2b
Calculated MW 152.6kDa
Description This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
Immunogen Purified recombinant fragment of human FBXL10 (AA: 457-555) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 84678
Other Names Lysine-specific demethylase 2B,, CXXC-type zinc finger protein 2, F-box and leucine-rich repeat protein 10, F-box protein FBL10, F-box/LRR-repeat protein 10, JmjC domain-containing histone demethylation protein 1B, Jumonji domain-containing EMSY-interactor methyltransferase motif protein, Protein JEMMA, Protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, KDM2B, CXXC2, FBL10, FBXL10, JHDM1B, PCCX2
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXL10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM2B
Synonyms CXXC2, FBL10, FBXL10, JHDM1B, PCCX2
Function Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Cellular Location Nucleus, nucleolus
Citations (0)

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1.Cancer Res. 2014 Jul 15;74(14):3935-46.2.Elife. 2012 Dec 18;1:e00205.

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$ 385.00
Cat# AO2175a
(40 western blots)
Availability: 7-10 days
Bulk Size
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