|Application ||WB, IHC, FC, ICC, E|
|Description||AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.|
|Immunogen||Purified recombinant fragment of human AIM2 (AA: 1-195) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Interferon-inducible protein AIM2, Absent in melanoma 2, AIM2|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AIM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.|
|Cellular Location||Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles|
|Tissue Location||Expressed in spleen, small intestine, peripheral blood leukocytes, and testis|
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1.Int J Cancer. 2014 Nov 15;135(10):2387-96.2.Mol Cancer Res. 2013 Oct;11(10):1193-202.
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