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IL28A Antibody

Purified Mouse Monoclonal Antibody

  • E - IL28A Antibody AO2197a

    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

  • WB - IL28A Antibody AO2197a

    Figure 2:Western blot analysis using IL28A mAb against human IL28A (AA: 1-200) recombinant protein. (Expected MW is 48.2 kDa)

  • WB - IL28A Antibody AO2197a

    Figure 3:Western blot analysis using IL28A mAb against HEK293 (1) and IL28A (AA: 1-200)-hIgGFc transfected HEK293 (2) cell lysate.

  • WB - IL28A Antibody AO2197a

    Figure 4:Western blot analysis using IL28A mouse mAb against SK-Br-3 (1) cell lysate.

  • IHC - IL28A Antibody AO2197a

    Figure 5:Immunohistochemical analysis of paraffin-embedded brain tissues using IL28A mouse mAb with DAB staining.

  • IHC - IL28A Antibody AO2197a

    Figure 6:Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using IL28A mouse mAb with DAB staining.

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IZJ0
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7B9A4
Isotype IgG1
Calculated MW 22.3kDa
Description This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
Immunogen Purified recombinant fragment of human IL28A (AA: 1-200) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 282616
Other Names Interferon lambda-2, IFN-lambda-2, Cytokine Zcyto20, Interleukin-28A, IL-28A, IFNL2, IL28A, ZCYTO20
Dilution E~~1/10000
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL28A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFNL2
Synonyms IL28A, ZCYTO20
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Cellular Location Secreted.
Research Areas
Citations (0)

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1.Cell Immunol. 2014 Jul;290(1):116-9.2.Cell Signal. 2012 Sep;24(9):1734-42.

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$ 385.00
Cat# AO2197a
(40 western blots)
Availability: 7-10 days
Bulk Size
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