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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   JARID2 Antibody   

JARID2 Antibody

Purified Mouse Monoclonal Antibody

  • E - JARID2 Antibody AO2206a

    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

  • WB - JARID2 Antibody AO2206a

    Figure 2:Western blot analysis using JARID2 mAb against human JARID2 (AA: 1097-1246) recombinant protein. (Expected MW is 42.7 kDa)

  • WB - JARID2 Antibody AO2206a

    Figure 3:Western blot analysis using JARID2 mAb against HEK293 (1) and JARID2 (AA: 1097-1246)-hIgGFc transfected HEK293 (2) cell lysate.

  • IF - JARID2 Antibody AO2206a

    Figure 4:Immunofluorescence analysis of Hela cells using JARID2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

  • FC - JARID2 Antibody AO2206a

    Figure 5:Flow cytometric analysis of Hela cells using JARID2 mouse mAb (green) and negative control (red).

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92833
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7H1B3
Isotype IgG2a
Calculated MW 139kDa
Description This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies.
Immunogen Purified recombinant fragment of human JARID2 (AA: 1097-1246) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 3720
Other Names Protein Jumonji, Jumonji/ARID domain-containing protein 2, JARID2, JMJ
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsJARID2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms JMJ
Function Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:20075857}. Note=Colocalizes with the PRC2 complex on chromatin
Tissue Location During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells
Research Areas
Citations (0)

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1.PLoS One. 2014 Dec 26;9(12):e115684.2.Am J Hematol. 2012 Mar;87(3):245-50.

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$ 385.00
Cat# AO2206a
(40 western blots)
Availability: 7-10 days
Bulk Size
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