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GFPT1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC, E |
|---|---|
| Primary Accession | Q06210 |
| Reactivity | Human, Rat, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1F1A4 |
| Isotype | IgG1 |
| Calculated MW | 78.8kDa |
| Description | This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. |
| Immunogen | Purified recombinant fragment of human GFPT1 (AA: 536-681) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 2673 |
|---|---|
| Other Names | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, 2.6.1.16, D-fructose-6-phosphate amidotransferase 1, Glutamine:fructose-6-phosphate amidotransferase 1, GFAT 1, GFAT1, Hexosephosphate aminotransferase 1, GFPT1, GFAT, GFPT |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GFPT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GFPT1 |
|---|---|
| Synonyms | GFAT, GFPT |
| Function | Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). |
| Tissue Location | Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Neurology. 2013 Jul 23;81(4):370-8.2.Hum Mol Genet. 2013 Jul 15;22(14):2905-13.
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$ 385.00
Cat# AO2211a
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