|Application ||WB, IHC, FC, ICC, E|
|Reactivity||Human, Rat, Monkey|
|Description||This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate.|
|Immunogen||Purified recombinant fragment of human GFPT1 (AA: 536-681) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, 188.8.131.52, D-fructose-6-phosphate amidotransferase 1, Glutamine:fructose-6-phosphate amidotransferase 1, GFAT 1, GFAT1, Hexosephosphate aminotransferase 1, GFPT1, GFAT, GFPT|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GFPT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.|
|Tissue Location||Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle.|
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1.Neurology. 2013 Jul 23;81(4):370-8.2.Hum Mol Genet. 2013 Jul 15;22(14):2905-13.
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