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ALDH6A1 Antibody

Purified Mouse Monoclonal Antibody

     
  • E - ALDH6A1 Antibody AO2230a

    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

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  • WB - ALDH6A1 Antibody AO2230a

    Figure 2:Western blot analysis using ALDH6A1 mAb against human ALDH6A1 (AA: 1-195) recombinant protein. (Expected MW is 47.2 kDa)

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  • WB - ALDH6A1 Antibody AO2230a

    Figure 3:Western blot analysis using ALDH6A1 mAb against HEK293 (1) and ALDH6A1 (AA: 1-195)-hIgGFc transfected HEK293 (2) cell lysate.

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  • WB - ALDH6A1 Antibody AO2230a

    Figure 4:Western blot analysis using ALDH6A1 mouse mAb against Jurkat (1), HEK293 (2), Hela (3), MCF-7 (4), and LNcap (5) cell lysate.

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  • IF - ALDH6A1 Antibody AO2230a

    Figure 5:Immunofluorescence analysis of Hela cells using ALDH6A1 mouse mAb. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

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  • IF - ALDH6A1 Antibody AO2230a

    Figure 6:Immunofluorescence analysis of Hela cells using ALDH6A1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

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  • FC - ALDH6A1 Antibody AO2230a

    Figure 7:Flow cytometric analysis of Hela cells using ALDH6A1 mouse mAb (green) and negative control (red).

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  • IHC - ALDH6A1 Antibody AO2230a

    Figure 8:Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ALDH6A1 mouse mAb with DAB staining.

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  • IHC - ALDH6A1 Antibody AO2230a

    Figure 9:Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using ALDH6A1 mouse mAb with DAB staining.

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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, FC, ICC, E
Primary Accession Q02252
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6H9B8
Isotype IgG1
Calculated MW 57.8kDa
Description This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants.
Immunogen Purified recombinant fragment of human ALDH6A1 (AA: 1-195) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 4329
Other Names Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial, MMSDH, Malonate-semialdehyde dehydrogenase [acylating], 1.2.1.18, 1.2.1.27, Aldehyde dehydrogenase family 6 member A1, ALDH6A1, MMSDH
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALDH6A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH6A1 (HGNC:7179)
Function Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.
Cellular Location Mitochondrion.
Research Areas
Citations (0)
citation

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References

1.Orphanet J Rare Dis. 2013 Jul 9;8:98.2.J Inherit Metab Dis. 2012 May;35(3):437-42.

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$ 385.00
Cat# AO2230a
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