|Application ||WB, E|
|Description||Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney|
|Immunogen||Purified recombinant fragment of human RNLS (AA: 68-242) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Renalase, 22.214.171.124, Monoamine oxidase-C, MAO-C, alpha-NAD(P)H oxidase/anomerase, RNLS, C10orf59|
WB~~1/500 - 1/2000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNLS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidation of the less abundant 1,2- dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta- NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.|
|Tissue Location||Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.|
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Provided below are standard protocols that you may find useful for product applications.
1.Kidney Blood Press Res. 2014;39(1):58-64.2.Ren Fail. 2013;35(5):673-9.
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