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BMPR1A Antibody

Purified Mouse Monoclonal Antibody

  • E - BMPR1A Antibody AO2247a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - BMPR1A Antibody AO2247a
    Figure 1: Western blot analysis using BMPR1A mAb against human BMPR1A recombinant protein. (Expected MW is 48.1 kDa)
  • WB - BMPR1A Antibody AO2247a
    Figure 2: Western blot analysis using BMPR1A mAb against HEK293 (1) and BMPR1A (AA: 179-378)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - BMPR1A Antibody AO2247a
    Figure 3: Flow cytometric analysis of Jurkat cells using BMPR1A mouse mAb (green) and negative control (purple).
  • IHC - BMPR1A Antibody AO2247a
    Figure 4: Immunohistochemical analysis of paraffin-embedded colon cancer tissues using BMPR1A mouse mAb with DAB staining.
  • IHC - BMPR1A Antibody AO2247a
    Figure 5: Immunohistochemical analysis of paraffin-embedded kidney tissues using BMPR1A mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P36894
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4B7B2
Isotype IgG1
Calculated MW 60kDa
Description The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
Immunogen Purified recombinant fragment of human BMPR1A (AA: 179-378 ) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 657
Other Names Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A,, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBMPR1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ACVRLK3, ALK3
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in skeletal muscle.
Research Areas
Citations (0)

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1.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 May 1;67(Pt 5):551-5. 2.Gastroenterology. 2011 Jul;141(1):e23-6.

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$ 385.00
Cat# AO2247a
(40 western blots)
Availability: 7-10 days
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