|Application ||WB, IHC, FC, E|
|Reactivity||Human, Mouse, Monkey|
|Description||The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.|
|Immunogen||Purified recombinant fragment of human SLC27A5 (AA: 508-570 ) expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Bile acyl-CoA synthetase, BACS, 184.108.40.206, Bile acid-CoA ligase, BA-CoA ligase, BAL, Cholate--CoA ligase, Fatty acid transport protein 5, FATP-5, Fatty-acid-coenzyme A ligase, very long-chain 3, Solute carrier family 27 member 5, Very long-chain acyl-CoA synthetase homolog 2, VLCS-H2, VLCSH2, Very long-chain acyl-CoA synthetase-related protein, VLACS-related, VLACSR, SLC27A5, ACSB, ACSVL6, FACVL3, FATP5|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC27A5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACSB, ACSVL6, FACVL3, FATP5|
|Function||Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Predominantly expressed in liver.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
1.Horm Metab Res. 2010 Nov;42(12):854-9. 2.Mol Nutr Food Res. 2007 Feb;51(2):185-91.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.