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CBX8 Antibody

Purified Mouse Monoclonal Antibody

  • E - CBX8 Antibody AO2267a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - CBX8 Antibody AO2267a
    Figure 1: Western blot analysis using CBX8 mAb against human CBX8 recombinant protein. (Expected MW is 49.5 kDa)
  • WB - CBX8 Antibody AO2267a
    Figure 2: Western blot analysis using CBX8 mAb against HEK293 (1) and CBX8 (AA: 17-222)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - CBX8 Antibody AO2267a
    Figure 3: Flow cytometric analysis of HeLa cells using CBX8 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HC52
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 9C3D4
Isotype IgG1
Calculated MW 43.4kDa
Description Chromobox homolog 8 (CBX8), a Polycomb Group protein that interacts with MLL-AF9 and TIP60, plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. CBX8, which is part of one of the PRC1 complexes, regulates proliferation of diploid human and mouse fibroblasts through direct binding to the INK4A-ARF locus.
Immunogen Purified recombinant fragment of human CBX8 (AA: 17-222) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 57332
Other Names Chromobox protein homolog 8, Polycomb 3 homolog, Pc3, hPc3, Rectachrome 1, CBX8, PC3, RC1
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCBX8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX8
Synonyms PC3, RC1
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Cellular Location Nucleus.
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1.Cancer Cell. 2011 Nov 15;20(5):563-75. 2.EMBO J. 2007 Mar 21;26(6):1637-48.

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$ 385.00
Cat# AO2267a
(40 western blots)
Availability: 7-10 days
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