|Application ||WB, E|
|Description||The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.|
|Immunogen||Purified recombinant fragment of human GNL3 (AA: 1-226) expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Guanine nucleotide-binding protein-like 3, E2-induced gene 3 protein, Novel nucleolar protein 47, NNP47, Nucleolar GTP-binding protein 3, Nucleostemin, GNL3, E2IG3, NS|
WB~~1/500 - 1/2000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNL3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).|
|Cellular Location||Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus|
|Tissue Location||Increased levels in lung tissue in cancer patients.|
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Provided below are standard protocols that you may find useful for product applications.
1.Oncogene. 2011 Apr 7;30(14):1716-26. 2.J Cell Biol. 2009 Jun 1;185(5):827-39.
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