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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   C17ORF53 Antibody   

C17ORF53 Antibody

Purified Mouse Monoclonal Antibody

  • E - C17ORF53 Antibody AO2275a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - C17ORF53 Antibody AO2275a
    Figure 1: Western blot analysis using C17ORF53 mAb against human C17ORF53 recombinant protein. (Expected MW is 51.9 kDa)
  • WB - C17ORF53 Antibody AO2275a
    Figure 2: Western blot analysis using C17ORF53 mAb against HEK293 (1) and C17ORF53 (AA: 282-527)-hIgGFc transfected HEK293 (2) cell lysate.
  • IF - C17ORF53 Antibody AO2275a
    Figure 3: Immunofluorescence analysis of HepG2 cells using C17ORF53 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
  • FC - C17ORF53 Antibody AO2275a
    Figure 4: Flow cytometric analysis of Jurkat cells using C17ORF53 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N3J3
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7A3A9
Isotype IgG2b
Calculated MW 69.8kDa
Description C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
Immunogen Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 78995
Other Names Uncharacterized protein C17orf53, C17orf53
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsC17ORF53 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name C17orf53
Research Areas
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1.Nat Genet. 2009 Jan;41(1):15-7.

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$ 385.00
Cat# AO2275a
(40 western blots)
Availability: 7-10 days
Bulk Size
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