|Application ||WB, FC, E|
|Reactivity||Human, Mouse, Rat|
|Description||The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.|
|Immunogen||Purified recombinant fragment of human PDE1B (AA: 370-536) expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1B, Cam-PDE 1B, 22.214.171.124, 63 kDa Cam-PDE, PDE1B, PDE1B1, PDES1B|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.|
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Provided below are standard protocols that you may find useful for product applications.
1.J Biol Chem. 2007 Nov 9;282(45):32749-57. 2.Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):497-502.
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