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FCER1A Antibody

Purified Mouse Monoclonal Antibody

     
  • E - FCER1A Antibody AO2285a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

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  • WB - FCER1A Antibody AO2285a
    Figure 1: Western blot analysis using FCER1A mAb against human FCER1A recombinant protein. (Expected MW is 32.5 kDa)
    detail
  • WB - FCER1A Antibody AO2285a
    Figure 2: Western blot analysis using FCER1A mouse mAb against SW620 (1), A549 (2), and A431 (3) cell lysate.
    detail
  • FC - FCER1A Antibody AO2285a
    Figure 3: Flow cytometric analysis of HEK293 cells using FCER1A mouse mAb (green) and negative control (red).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P12319
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1F2A9
Isotype IgG1
Calculated MW 29.6kDa
Description The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit.
Immunogen Purified recombinant fragment of human FCER1A (AA: 42-103) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 2205
Other Names High affinity immunoglobulin epsilon receptor subunit alpha, Fc-epsilon RI-alpha, FcERI, IgE Fc receptor subunit alpha, FCER1A, FCE1A
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFCER1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCER1A
Synonyms FCE1A
Function High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in eosinophils.
Research Areas
Citations (0)
citation

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References

1.Hum Immunol. 2012 Mar;73(3):301-5. 2.Mol Immunol. 2011 Apr;48(8):979-80.

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$ 385.00
Cat# AO2285a
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Availability: 7-10 days
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