|Application ||WB, IHC, FC, ICC, E|
|Description||Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene.|
|Immunogen||Purified recombinant fragment of human GUCY1A3 (AA: 22-214) expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||Guanylate cyclase soluble subunit alpha-3, GCS-alpha-3, 188.8.131.52, GCS-alpha-1, Soluble guanylate cyclase large subunit, GUCY1A3, GUC1A3, GUCSA3, GUCY1A1|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GUCY1A3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Detected in brain cortex and lung (at protein level).|
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1.Mol Endocrinol. 2012 Feb;26(2):292-307. 2.J Biol Inorg Chem. 2011 Dec;16(8):1227-39.
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