|Application ||WB, IHC, FC, ICC, E|
|Description||Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility.|
|Immunogen||Purified recombinant fragment of human CLGN (AA: 249-405) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Calmegin, CLGN|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLGN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in testis (at protein level). Detected in testis.|
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Provided below are standard protocols that you may find useful for product applications.
1.Arch Histol Cytol. 1999 Aug;62(3):283-93. 2.Dev Biol. 2001 Dec 1;240(1):254-61.
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