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TP53BP1 Antibody

Purified Mouse Monoclonal Antibody

  • E - TP53BP1 Antibody AO2317a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - TP53BP1 Antibody AO2317a
    Figure 1: Western blot analysis using TP53BP1 mAb against human TP53BP1 recombinant protein. (Expected MW is 47.6 kDa)
  • WB - TP53BP1 Antibody AO2317a
    Figure 2: Western blot analysis using TP53BP1 mAb against HEK293 (1) and TP53BP1 (AA: 574-773)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - TP53BP1 Antibody AO2317a
    Figure 3: Flow cytometric analysis of HepG2 cells using TP53BP1 mouse mAb (green) and negative control (purple).
  • IHC - TP53BP1 Antibody AO2317a
    Figure 4: Immunohistochemical analysis of paraffin-embedded colon cancer tissues using TP53BP1 mouse mAb with DAB staining.
  • IHC - TP53BP1 Antibody AO2317a
    Figure 5: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using TP53BP1 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12888
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6B3E10
Isotype IgG1
Calculated MW 213.6kDa
Description T protein p53 binding protein 1 may have a role in checkpoint signaling during mitosis,enhance TP53-mediated transcriptional activation and play a role in the response to DNA damage.
Immunogen Purified recombinant fragment of human TP53BP1 (AA: 574-773) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 7158
Other Names Tumor suppressor p53-binding protein 1, 53BP1, p53-binding protein 1, p53BP1, TP53BP1
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTP53BP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TP53BP1
Function Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation.
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed
Research Areas
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1. Cancer Res. 2012 Oct 1;72(19):4974-83. 2. Int J Biochem Cell Biol. 2012 Sep;44(9):1398-409.

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$ 385.00
Cat# AO2317a
(40 western blots)
Availability: 7-10 days
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