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ITGA2B Antibody

Purified Mouse Monoclonal Antibody

  • E - ITGA2B Antibody AO2320a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - ITGA2B Antibody AO2320a
    Figure 1: Western blot analysis using ITGA2B mAb against human ITGA2B recombinant protein. (Expected MW is 36.9 kDa)
  • WB - ITGA2B Antibody AO2320a
    Figure 2: Western blot analysis using ITGA2B mAb against HEK293 (1) and ITGA2B (AA: 45-149)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - ITGA2B Antibody AO2320a
    Figure 4: Flow cytometric analysis of HL60 cells using ITGA2B mouse mAb (green) and negative control (purple).
  • IHC - ITGA2B Antibody AO2320a
    Figure 5: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using ITGA2B mouse mAb with DAB staining.
  • IHC - ITGA2B Antibody AO2320a
    Figure 6: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ITGA2B mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08514
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2E10C9
Isotype IgG1
Calculated MW 113.4kDa
Description ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Immunogen Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 3674
Other Names Integrin alpha-IIb, GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb, CD41, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2, ITGA2B, GP2B, ITGAB
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsITGA2B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GP2B, ITGAB
Function Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells
Research Areas
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1. Pediatr Blood Cancer. 2012 Aug;59(2):335-8. 2. Blood. 2011 Dec 1;118(23):5996-6005.

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$ 385.00
Cat# AO2320a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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