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Mouse Monoclonal Antibody to PELP1
Purified Mouse Monoclonal Antibody
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- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q8IZL8 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2D6D11 |
| Isotype | Mouse IgG2a |
| Calculated MW | 120kDa |
| Description | This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants.; |
| Immunogen | Purified recombinant fragment of human PELP1 (AA: 1031-1180) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 FCM: 1/200 - 1/400 |
| Gene ID | 27043 |
|---|---|
| Other Names | MNAR; P160 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to PELP1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PELP1 |
|---|---|
| Synonyms | HMX3, MNAR |
| Function | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. |
| Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Cytoplasm Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors (PubMed:16140940). {ECO:0000250|UniProtKB:Q9DBD5, ECO:0000269|PubMed:16140940} |
| Tissue Location | Widely expressed.. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.BMC Cancer. 2013 Mar 14;13:115. ; 2.Oncol Rep. 2012 Dec;28(6):2035-42. ;
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$ 385.00
Cat# AO2335a
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