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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Monoclonal Antibody to XRN2   

Mouse Monoclonal Antibody to XRN2

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to XRN2 AO2345a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • WB - Mouse Monoclonal Antibody to XRN2 AO2345a
    Western blot analysis using XRN2 mAb against human XRN2 (AA: 398-547) recombinant protein. (Expected MW is 43.1 kDa)
  • WB - Mouse Monoclonal Antibody to XRN2 AO2345a
    Western blot analysis using XRN2 mAb against HEK293 (1) and XRN2 (AA: 398-547)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - Mouse Monoclonal Antibody to XRN2 AO2345a
    Western blot analysis using XRN2 mouse mAb against HEK293 (1), NTERA-2 (2), LNcap (3), HepG2 (4), and PC-3 (5) cell lysate.
  • IHC - Mouse Monoclonal Antibody to XRN2 AO2345a
    Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using XRN2 mouse mAb with DAB staining.
  • IHC - Mouse Monoclonal Antibody to XRN2 AO2345a
    Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using XRN2 mouse mAb with DAB staining.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession Q9H0D6
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 9F7G11
Isotype Mouse IgG1
Calculated MW 108.5kDa
Description This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.;
Immunogen Purified recombinant fragment of human XRN2 (AA: 398-547) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
IHC: 1/200 - 1/1000
Additional Information
Gene ID 22803
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to XRN2 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name XRN2
Function Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
Cellular Location Nucleus, nucleolus
Tissue Location Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
Research Areas
Citations (0)

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References

1.EMBO J. 2012 May 30;31(11):2566-78. ; 2.DNA Seq. 2005 Apr;16(2):143-6.;

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$ 385.00
Cat# AO2345a
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