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Mouse Monoclonal Antibody to PGRMC1

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to PGRMC1 AO2363a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
    detail
  • WB - Mouse Monoclonal Antibody to PGRMC1 AO2363a
    Western blot analysis using PGRMC1 mAb against human PGRMC1 (AA: 1-195) recombinant protein. (Expected MW is 47.6 kDa)
    detail
  • WB - Mouse Monoclonal Antibody to PGRMC1 AO2363a
    Western blot analysis using PGRMC1 mAb against HEK293 (1) and PGRMC1 (AA: 1-195)-hIgGFc transfected HEK293 (2) cell lysate.
    detail
  • FC - Mouse Monoclonal Antibody to PGRMC1 AO2363a
    Flow cytometric analysis of A549 cells using PGRMC1 mouse mAb (green) and negative control (red).
    detail
  • ICC - Mouse Monoclonal Antibody to PGRMC1 AO2363a
    Immunofluorescence analysis of SK-OV-3 cells using PGRMC1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher
    detail
  • IHC - Mouse Monoclonal Antibody to PGRMC1 AO2363a
    Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using PGRMC1 mouse mAb with DAB staining.
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  • IHC - Mouse Monoclonal Antibody to PGRMC1 AO2363a
    Immunohistochemical analysis of paraffin-embedded breast cancer tissues using PGRMC1 mouse mAb with DAB staining.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, FC, ICC, E
Primary Accession O00264
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7G11G8
Isotype Mouse IgG1
Calculated MW 21.7kDa
Description This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney.;
Immunogen Purified recombinant fragment of human PGRMC1 (AA: 1-195) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
IHC: 1/200 - 1/1000
ICC: 1/200 - 1/1000
FCM: 1/200 - 1/400
Additional Information
Gene ID 10857
Other Names MPR; HPR6.6
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to PGRMC1 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PGRMC1 (HGNC:16090)
Function Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).
Cellular Location Microsome membrane {ECO:0000250|UniProtKB:Q95250}; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane {ECO:0000250|UniProtKB:O55022}; Single-pass membrane protein; Extracellular side {ECO:0000250|UniProtKB:O55022} Secreted
Tissue Location Detected in urine (at protein level) (PubMed:36213313, PubMed:37453717). Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Widely expressed, with highest expression in liver and kidney.
Research Areas
Citations (0)
citation

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References

1.Cancer Lett. 2015 Jan 28;356(2 Pt B):434-42. ; 2.Nan Fang Yi Ke Da Xue Xue Bao. 2012 May;32(5):635-8. ;

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$ 385.00
Cat# AO2363a
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