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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Monoclonal Antibody to TTF1   

Mouse Monoclonal Antibody to TTF1

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to TTF1 AO2367a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • WB - Mouse Monoclonal Antibody to TTF1 AO2367a
    Western blot analysis using TTF1 mAb against human TTF1 (AA: 1-150) recombinant protein. (Expected MW is 43.5 kDa)
  • WB - Mouse Monoclonal Antibody to TTF1 AO2367a
    Western blot analysis using TTF1 mAb against HEK293 (1) and TTF1 (AA: 1-150)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - Mouse Monoclonal Antibody to TTF1 AO2367a
    Flow cytometric analysis of Hela cells using TTF1 mouse mAb (green) and negative control (red).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q15361
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2F4B12
Isotype Mouse IgG1
Calculated MW 103kDa
Description This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.;
Immunogen Purified recombinant fragment of human TTF1 (AA: 1-150) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
FCM: 1/200 - 1/400
Additional Information
Gene ID 7270
Other Names TTF-1; TTF-I
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to TTF1 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TTF1
Function Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
Cellular Location Nucleus. Nucleus, nucleolus.
Research Areas
Citations (0)

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References

1.Tumour Biol. 2015 Sep;36(10):8085-92. ; 2.Chest. 2013 Oct;144(4):1199-206.;

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$ 385.00
Cat# AO2367a
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