Mouse Monoclonal Antibody to VIMP
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, ICC, E |
---|---|
Primary Accession | Q9BQE4 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 5G4A10 |
Isotype | Mouse IgG1 |
Calculated MW | 21.2kDa |
Description | This gene encodes a member of the selenoprotein family, characterized by a selenocysteine (Sec) residue at the active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Alternative splicing results in multiple transcript variants encoding different isoforms.; |
Immunogen | Purified recombinant fragment of human VIMP (AA: 1-187) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 ICC: 1/50 - 1/250 FCM: 1/200 - 1/400 |
Gene ID | 55829 |
---|---|
Other Names | SELS; ADO15; SBBI8; SEPS1; AD-015 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Monoclonal Antibody to VIMP is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SELENOS {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:30396} |
---|---|
Function | Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
1.Free Radic Biol Med. 2014 Feb;67:265-77. ; 2.PLoS One. 2013 Jun 11;8(6):e65657.;
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.