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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Monoclonal Antibody to RALB   

Mouse Monoclonal Antibody to RALB

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to RALB AO2448a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • WB - Mouse Monoclonal Antibody to RALB AO2448a
    Western blot analysis using RALB mAb against human RALB (AA: 89-206) recombinant protein. (Expected MW is 39.7 kDa)
  • WB - Mouse Monoclonal Antibody to RALB AO2448a
    Western blot analysis using RALB mAb against HEK293 (1) and RALB (AA: 89-206)-hIgGFc transfected HEK293 (2) cell lysate.
  • WB - Mouse Monoclonal Antibody to RALB AO2448a
    Western blot analysis using RALB mouse mAb against A549 (1), U251 (2), HT-29 (3), HEK293 (4), and LOVO (5) cell lysate.
  • FC - Mouse Monoclonal Antibody to RALB AO2448a
    Flow cytometric analysis of Hela cells using RALB mouse mAb (green) and negative control (red).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P11234
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8A8A9
Isotype Mouse IgG2a
Calculated MW 23.4kDa
Description This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.;
Immunogen Purified recombinant fragment of human RALB (AA: 89-206) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
FCM: 1/200 - 1/400
Additional Information
Gene ID 5899
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to RALB is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RALB
Function Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=During late cytokinesis, enriched at the midbody.
Research Areas
Citations (0)

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References

1.Clin Transl Oncol. 2015 Jun;17(6):477-85. ; 2.Cancer Res. 2010 Nov 1;70(21):8760-9.;

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$ 385.00
Cat# AO2448a
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