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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Mouse Monoclonal Antibody to THBS1   

Mouse Monoclonal Antibody to THBS1

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to THBS1 AO2467a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • WB - Mouse Monoclonal Antibody to THBS1 AO2467a
    Western blot analysis using THBS1 mAb against human THBS1 (AA: 750-850) recombinant protein. (Expected MW is 37.3 kDa)
  • WB - Mouse Monoclonal Antibody to THBS1 AO2467a
    Western blot analysis using THBS1 mAb against HEK293 (1) and THBS1 (AA: 750-850)-hIgGFc transfected HEK293 (2) cell lysate.
  • FC - Mouse Monoclonal Antibody to THBS1 AO2467a
    Flow cytometric analysis of Hela cells using THBS1 mouse mAb (green) and negative control (red).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P07996
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5E2E2
Isotype Mouse IgG1
Calculated MW 129kDa
Description The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. ;
Immunogen Purified recombinant fragment of human THBS1 (AA: 750-850) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
FCM: 1/200 - 1/400
Additional Information
Gene ID 7057
Other Names TSP; THBS; TSP1; TSP-1; THBS-1
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to THBS1 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THBS1
Synonyms TSP, TSP1
Function Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
Cellular Location Secreted. Cell surface. Secreted, extracellular space, extracellular matrix Endoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P35441}. Note=Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993) Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). {ECO:0000250|UniProtKB:P35441, ECO:0000269|PubMed:6341993, ECO:0000269|PubMed:6777381}
Research Areas
Citations (0)

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References

1.Ren Fail. 2015 Jul;37(6):1039-43. ; 2.Int J Cardiol. 2013 Sep 30;168(2):692-706.;

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$ 385.00
Cat# AO2467a
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