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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Monoclonal Antibody to APBA2   

Mouse Monoclonal Antibody to APBA2

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to APBA2 AO2486a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • WB - Mouse Monoclonal Antibody to APBA2 AO2486a
    Western blot analysis using APBA2 mAb against human APBA2 (AA: 15-158) recombinant protein. (Expected MW is 42 kDa)
  • WB - Mouse Monoclonal Antibody to APBA2 AO2486a
    Western blot analysis using APBA2 mAb against HEK293 (1) and APBA2 (AA: 15-158)-hIgGFc transfected HEK293 (2) cell lysate.
  • ICC - Mouse Monoclonal Antibody to APBA2 AO2486a
    Immunofluorescence analysis of Hela cells using APBA2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, ICC, E
Primary Accession Q99767
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1C12A4
Isotype Mouse IgG1
Calculated MW 82.5kDa
Description The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.;
Immunogen Purified recombinant fragment of human APBA2 (AA: 15-158) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
ICC: 1/50 - 1/200
Additional Information
Gene ID 321
Other Names X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to APBA2 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APBA2
Synonyms MINT2, X11L
Function Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
Tissue Location Brain.
Research Areas
Citations (0)

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References

1.Neuroreport. 2012 Feb 15;23(3):146-51. ; 2.Autism Res. 2009 Dec;2(6):359-64. ;

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$ 385.00
Cat# AO2486a
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