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Mouse Monoclonal Antibody to APBA2
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, E |
|---|---|
| Primary Accession | Q99767 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1C12A4 |
| Isotype | Mouse IgG1 |
| Calculated MW | 82.5kDa |
| Description | The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.; |
| Immunogen | Purified recombinant fragment of human APBA2 (AA: 15-158) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 ICC: 1/50 - 1/200 |
| Gene ID | 321 |
|---|---|
| Other Names | X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to APBA2 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APBA2 |
|---|---|
| Synonyms | MINT2, X11L |
| Function | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
| Tissue Location | Brain. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Neuroreport. 2012 Feb 15;23(3):146-51. ; 2.Autism Res. 2009 Dec;2(6):359-64. ;
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$ 385.00
Cat# AO2486a
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