|Application ||WB, ICC, E|
|Description||The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.;|
|Immunogen||Purified recombinant fragment of human APBA2 (AA: 15-158) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Application Note||ELISA: 1/10000|
WB: 1/500 - 1/2000
ICC: 1/50 - 1/200
|Other Names||X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Monoclonal Antibody to APBA2 is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.|
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Provided below are standard protocols that you may find useful for product applications.
1.Neuroreport. 2012 Feb 15;23(3):146-51. ; 2.Autism Res. 2009 Dec;2(6):359-64. ;
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