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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Monoclonal Antibody to CBX7   

Mouse Monoclonal Antibody to CBX7

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to CBX7 AO2489a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
  • WB - Mouse Monoclonal Antibody to CBX7 AO2489a
    Western blot analysis using CBX7 mAb against human CBX7 (AA: 15-147) recombinant protein. (Expected MW is 41.6 kDa)
  • WB - Mouse Monoclonal Antibody to CBX7 AO2489a
    Western blot analysis using CBX7 mAb against HEK293 (1) and CBX7 (AA: 15-147)-hIgGFc transfected HEK293 (2) cell lysate.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O95931
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3H9C4
Isotype Mouse IgG1
Calculated MW 28.3kDa
Description CBX7 (Chromobox 7) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and single-stranded RNA binding. An important paralog of this gene is CBX4.;
Immunogen Purified recombinant fragment of human CBX7 (AA: 15-147) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
Additional Information
Gene ID 23492
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to CBX7 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX7
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Cellular Location Nucleus
Research Areas
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References

1.PLoS One. 2014 May 27;9(5):e98295. ; 2.Eur J Cancer. 2010 Aug;46(12):2304-13.;

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$ 385.00
Cat# AO2489a
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