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Mouse Monoclonal Antibody to CBX7
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95931 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3H9C4 |
| Isotype | Mouse IgG1 |
| Calculated MW | 28.3kDa |
| Description | CBX7 (Chromobox 7) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and single-stranded RNA binding. An important paralog of this gene is CBX4.; |
| Immunogen | Purified recombinant fragment of human CBX7 (AA: 15-147) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 |
| Gene ID | 23492 |
|---|---|
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to CBX7 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CBX7 |
|---|---|
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. |
| Cellular Location | Nucleus |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.PLoS One. 2014 May 27;9(5):e98295. ; 2.Eur J Cancer. 2010 Aug;46(12):2304-13.;
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$ 385.00
Cat# AO2489a
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