TFAP2C
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC, E |
---|---|
Primary Accession | Q92754 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 3A11A5 |
Isotype | Mouse IgG1 |
Calculated MW | 49.2kDa |
Immunogen | Purified recombinant fragment of human TFAP2C (AA: 341-450) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Gene ID | 7022 |
---|---|
Other Names | ERF1; TFAP2G; hAP-2g; AP2-GAMMA |
Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 IHC~~1/200 - 1/1000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TFAP2C is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TFAP2C |
---|---|
Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
References
1.Breast Cancer Res Treat. 2015 Aug;152(3):519-31.2.Ann Surg Oncol. 2013 Jul;20(7):2204-12.
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