PLXNA1
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC, E |
---|---|
Primary Accession | Q9UIW2 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 7B8H9 |
Isotype | Mouse IgG2b |
Calculated MW | 211kDa |
Immunogen | Purified recombinant fragment of human PLXNA1 (AA: 1100-1200) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Gene ID | 5361 |
---|---|
Other Names | NOV; NOVP; PLXN1; PLEXIN-A1 |
Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 FCM~~1/200 - 1/400 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PLXNA1 is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLXNA1 (HGNC:9099) |
---|---|
Synonyms | NOV, PLXN1 |
Function | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Detected in fetal brain, lung, liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
References
1.PLoS One. 2016 Mar 10;11(3):e0149833. 2.World J Gastroenterol. 2007 Dec 28;13(48):6558-61.
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