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B7H3

Purified Mouse Monoclonal Antibody

     
  • E - B7H3 AO2699a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
    detail
  • WB - B7H3 AO2699a
    Figure 2:Western blot analysis using B7H3 mAb against human B7H3 (AA: extra 29-466) recombinant protein. (Expected MW is 76.9 kDa)
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E
Primary Accession Q5ZPR3
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5E1D9
Isotype Mouse IgG1
Calculated MW 57.2kDa
Immunogen Purified recombinant fragment of human B7H3 (AA: extra 29-466) expressed in HEK293 cells.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 80381
Other Names CD276; B7-H3; B7RP-2; 4Ig-B7-H3
Dilution E~~ 1/10000
WB~~ 1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsB7H3 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD276
Synonyms B7H3
Function May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.
Research Areas
Citations (0)
citation

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References

1.Int J Clin Exp Pathol. 2015 Nov 1;8(11):13987-95.2.BMC Cancer. 2014 Aug 20;14:602.

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$ 385.00
Cat# AO2699a
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