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VISTA
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | Q9H7M9 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6E4H3 |
| Isotype | Mouse IgG1 |
| Calculated MW | 34kDa |
| Immunogen | Purified recombinant fragment of human VISTA (AA: extra 33-194) expressed in HEK293 cells. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 64115 |
|---|---|
| Other Names | VSIR; B7H5; GI24; B7-H5; PD-1H; SISP1; PP2135; C10orf54; DD1alpha |
| Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 FCM~~ 1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VISTA is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VSIR (HGNC:30085) |
|---|---|
| Function | Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14- mediated MMP2 activation (PubMed:20666777). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea Has low expression levels in other tissues |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Cancer Res. 2014 Apr 1;74(7):1924-32.2.PLoS One. 2014 Oct 3;9(10):e109103.
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$ 385.00
Cat# AO2704a
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